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Such persistent autoantibodies are hypothesised to disturb vessel autoregulation, causing secondary metabolic and autonomic adaptations

J Parkinsons Dis 2018;8:563 3

This process ultimately triggers aging-related events, including the secretion of senescence-associated secretory phenotype (SASP) factors like IL-6 and IL-8 by aging cells, which are strongly correlated with histopathological features [77]