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The underlying mechanism(s) linking reduced IGF-1 signaling to improved mammalian lifespan is thought to involve improved stress defenses and lower risk for proliferative diseases 9,10,11 , though the reason for sex differences in this response remains unresolved

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The MAP kinase signal transduction pathway is activated by the endogenous cannabinoid anandamide

Glutathione has a main role not only in allowing native disulphide bonds to form, but also in balancing redox reactions and thereby protecting the cell from oxidative stress