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also, oxidative stress produces structural changes of cell membranes with decreased adhesion, and the migration of altered tumor cells in neighboring tissues or in distant blood and lymph (Forni et al., 2019)

Moreover, Hepatocyte-derived ceramide-dependent EVs are enriched in several distinct damage-associated molecular patterns and cellular adhesion molecules, including ICAM1 and S100A11, that may influence immune cell responses, leading to hepatocellular inflammation (84)

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