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High TNF-alpha plasma levels and macrophages iNOS and TNF-alpha expression as risk factors for painful diabetic neuropathy

They are related with inflammation and mitochondrial and proteasomal dysfunction

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When considering treatment effects under the assumption that all individuals adhered to the therapy1, participants administered CagriSema experienced a weight loss of 22.7% after 68 weeks, significantly exceeding the 11.8% loss with cagrilintide 2.4 mg, 16.1% with semaglutide 2.4 mg, and 2.3% with placebo