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While higher doses may be used short-term, long-term mega-dosing offers no added benefit and may cause mild digestive discomfort in some people

In T2D mouse models, sex-specific differences in GPER expression were observed, with female mice exhibiting significantly higher levels of GPER expression than male mice, while GPER expression decreased significantly following the induction of diabetes, implying that GPER expression influences the occurrence and development of diabetes

An #Unapproved drug has received approval to be compounded

10.1105/tpc.010538 102 PnueliL.LiangH.RozenbergM.MittlerR

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