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Description

pmid:24379283 70

In WD, a steadily copper pile-up has long been thought to elicit omnipresent toxic oxidative stress, ultimately sealing cellular and organismal fate

The reasons for delaying the start of pimobendan treatment until the dogs reached CHF has been due to prior peer-reviewed veterinary studies finding harmful side-effects if the dogs were treated before the need for the positive inotropic support of their hearts' contractility, which pimobendan provides