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Reinfusion: The filtered blood cells are returned to your body, along with a sterile replacement solution such as albumin or donor plasma

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To avoid confounding bias from the crossover intervention, data from this later phase will not be used for the primary hypothesis testing

The study discovered: -Markedly lower B12 levels in moderate and severe COVID-19 cases compared to controls -Elevated homocysteine, a B12-linked amino acid associated with clotting risk A correlation between B12 depletion, inflammation and respiratory impairment That study however only concluded that Vitamin B12 deficiencies were driving COVID-19 susceptibilities and but did not conclude that COVID-19 was actually driving Vitamin b12 itself Suggestive evidence that SARS-CoV-2 may reduce B12 availability even in individuals previously sufficient The researchers only noted that vitamin B12 interacts with essential lung-protective proteins such as alpha-1 antitrypsin (A1AT) and metabolizes homocysteinetwo factors tied direc tly to immune regulation and cardiovascular integrity