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[68] Several mechanisms have been proposed for this effect, including changes in the rate of breakdown of clotting factors and changes in the metabolism of warfarin

Zentralbl Veterinarmed A 38, 617-620

Lysosomal damage pathway: Upon phagocytosis by macrophages, crystals cause lysosomal membrane rupture, releasing cathepsin B, which activates the NLRP3 inflammasome (Kluck et al., 2021