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Pharmacol Rev 64:421449

In the absence of intracellular nucleophiles such as GSH, this reactive metabolite ( N -acetylbenzoiminoquinone) not only reacts with nucleophilic groups of cellular proteins resulting in direct hepatocellular damage, but also participates in redox cycling, thereby generating reactive O 2 species ( ROS ) and consequent oxidative stress that greatly enhance APAP-induced hepatotoxicity

Vitamin C is an antioxidant and is essential for the formation and stabilization of collagen and elastin

Anthrieu S, Bachour-El Azzi P, Dumont J et al (2013) Oxidative stress plays a major role in chlorpromazine-induced cholestasis in human HepaRG cells

Cryo-EM and artificial intelligence visualize endogenous protein community members