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Ann Pharmacother 2010;44(7-8):1287-93

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Several animal studies have reported that huperzine A may result in a more prolonged increase in acetylcholine in the whole brain when compared to other compounds that raise acetylcholine levels, such as tacrine , physostigmine , and metrifonate [5, 6, 7]

However, despite minimal sedation with propofol, the patient failed to wake when sedation was ceased