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Environ Sci Technol 47(24):1411014118

The use of trazodone hydrochloride tablets should be avoided in patients with known QT prolongation or in combination with other drugs that are inhibitors of CYP3A4 (e.g., itraconazole, clarithromycin, voriconazole), or known to prolong QT interval including Class 1A antiarrhythmics (e.g., quinidine, procainamide) or Class 3 antiarrhythmics (e.g., amiodarone, sotalol), certain antipsychotic medications (e.g., ziprasidone, chlorpromazine, thioridazine), and certain antibiotics (e.g., gatifloxacin)

These compounds were tested in colon cancer cells, where the chlorine-containing molecule [Cu(Trop)Cl] exhibited antiproliferative effects, a property not observed with the saccharin-containing molecule [Cu(Trop)Sac]