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Lastly, in contrast to GLO1, we found GLO2 protein levels to be downregulated and its precursor sLG to be upregulated by hypoxia in lung cancer cells, suggesting that hypoxic cells need to detoxify MG either by alternative routes 47,70 or perhaps they rather accumulate the nontoxic intermediate sLG than producing higher levels of D-lactate, which would further increase acidification next to the already upregulated anaerobic L-lactate production from pyruvate

Studies on the reactivity of CDDO, a promising new chemopreventive and chemotherapeutic agent: implications for a molecular mechanism of action

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Bioavailability is not just a buzzword