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Neuropediatrics (2007) 38:27681.10.1055/s-2008-1065354 92 MorettiPPetersSUDel GaudioDSahooTHylandKBottiglieriTet alBrief report: autistic symptoms, developmental regression, mental retardation, epilepsy, and dyskinesias in CNS folate deficiency

In addition to impaired oxygen consumption in patient brains, other experiments have observed decreased glucose metabolism, adding more proof of bioenergetic dysfunction and mitochondrial dysfunction in the disease [43]