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Finally, insights into the pharmacological targeting of cysteine metabolism will be presented

135 , 136 Furthermore, mutations in excision repair genes ERCC1 and ERCC4 (XPF) also render cells sensitive to cross-linking by alkylating agents, suggesting these genes play a role in the repair of cross-links in addition to their role in NER

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The results vary according to the desired degree of correction and the individuals physiological response to the treatment

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