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doi: 10.6515/ACS.202109_37(5).20210514A

However, this natural response can be slow, especially as we age or when dealing with significant tissue damage

doi: 10.3389/fimmu.2026.1726566 Received 16 October 2025 Revised 27 February 2026 Accepted 09 March 2026 Published 30 March 2026 Volume 17 - 2026 Edited by Christian David Sadik, University of Lbeck, Germany Reviewed by Zhaoqi Zhang, Chinese Academy of Sciences (CAS), China Yihua Fan, Hospital of Chengdu University of Traditional Chinese Medicine, China Updates Copyright 2026 Chen, Cheng, Li and Zhao

When used appropriately and under medical supervision, melatonin supplementation can improve sleep latency and duration, particularly in cases of jet lag, shift work sleep disorder, and delayed sleep-wake phase disorder (DSWPD)