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We contextualize this framework within global advances, including insights from the 2025 U.S

Adequate glutathione levels support the livers ability to process and eliminate toxins, heavy metals, and metabolic waste products

Though we did not distinguish the extent to which cysteine restriction influences these two routes of cytosolic cluster synthesis, our findings strongly reflect previous work demonstrating a sensitivity of the CIA to GSH limitation, as GSH is required in the assembly and maturation of cytosolic clusters 77,78

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