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Upon activation, the p38 MAPK signaling pathway induces robust oxidative stress response and triggers the release of a plethora of inflammatory factors, including TNF-, IL-1, and IL-6

Consequently, for a given intake level, a larger proportion of plant protein escapes digestion in the upper gastrointestinal tract and enters the colon, serving as a substrate for microbial fermentation

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These methodologies collectively provide a robust foundation for targeting ferroptosis in both basic research and translational medicine

Across most of the outcome measures analysed, cuprizone pellets were generally better than cuprizone powder at inducing early demyelinating disease pathology compared to their relative controls, particularly in the caudal corpus callosum (Table 1)