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This event was, however, not necessarily preceded by an oxidative burst and later on we demonstrated that GSH release was the result of an active process that the cells carried out through specific carriers in order to efficiently execute the apoptotic program ( necessary to induce the redox unbalance characteristic of the induction phase of the mitochondrial pathway but not sufficient per se to assure the execution phase of apoptosis

2009 M K Robinson, M L Rodrick, D O Jacobs, J D Rounds, K H Collins, I B Saporoschetz, J A Mannick, D W Wilmore

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Rapid evolution by positive Darwinian selection in T-cell antigen CD4 in primates

A meta-analysis of studies using NAC to increase athletic performance found that there were more side effects (none severe) at 20g/day.[ref] High doses of NAC are used in hospitals by IV for reversing acetaminophen toxicity