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Of note, G6PD can in turn decrease the levels of glucose6phosphate, thus potentially explaining downmodulation, by substrate subtraction, of the early glycolytic enzyme GPI (Dyson & Noltmann, 1968)

Bibcode:2017Sci...355.1312L

Nonetheless, more detailed studies are necessary to understand how epigenetic enzymes collaborate with NPAC/GLYR1 to distribute histone codes in actively transcribed genes during transcriptional elongation

Genetic variants in multisynthetase complex genes are associated with DNA damage levels in Chinese populations

Overall, mitochondrial diseases are increasingly recognized as pathway-based disorders rather than merely energy-related conditions