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Methotrexate induced intestine and nephrotoxicity attenuated by Andrographis paniculata via ameliorating oxidative stress, inflammation and apoptosis Advances in Traditional Medicine Springer Nature Link Transport and metabolism of methotrexate in humans. Methotrexate (MTX) Download Scientific Diagram Berberine ameliorates methotrexate induced liver injury by activating Nrf2 HO 1 pathway and PPAR, and suppressing oxidative stress and apoptosis in rats ScienceDirect Methotrexate induced hepatotoxicity mechanism, clinical cases and treatment approaches Toxicological Research Springer Nature Link Alpha lipoic acid exerts antioxidant effect via Nrf2 HO 1 pathway activation and suppresses hepatic stellate cells activation induced by methotrexate in rats ScienceDirect

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