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PallottiFPelloniMColangeloSGianfrilliDLenziALombardoFet al

In disease states, the acidic environment sustained by lactate can contribute to immunosuppressive or pro-inflammatory conditions, thereby exacerbating the progression of diseases such as sepsis, arthritis, autoimmune disorders, and cancer

Sherwood E.R

Chemical reagents and solvents were purchased from J&K Scientific, Sigma-Aldrich, ThermoFisher or Novabiochem

These pathways converge at the central metabolic intermediate crotonyl-CoA, with distinct synthesizing enzymes participating in each path: crotonase (Cro), 4-hydroxybutyryl dehydratase (4hbD), glutaconyl-CoA decarboxylase (Gcd), or 3-aminobutyryl-CoA ammonia lyase (Kal) (Fig