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These compounds are renally eliminated and can accumulate in patients with renal dysfunction and may play a role in the development of thrombocytopenia Chronic liver failure History of vancomycin use Low baseline platelet level of less than 200 Low body weightLinezolid dosing does not change for adults nor require renal or hepatic impairment adjustment

Distribution of variables known to be negative prognostic factors in relation to the achievement of spontaneous resolution during follow-up

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