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Targeting lysosomes in human disease: from basic research to clinical applications

Lyophilized tissue samples were extracted with formamide at 57 C for 24 h on a shaker at 300 rpm (Eppendorf Thermomixer)

Incapsula incident ID: 1849000641082654729-1049388461904695349

Diverse tau pathologies in late-life mood disorders revealed by PET and autopsy assays

In a mouse model of endotoxemia, LPS rapidly induced S100A8/A9 release and acute cardiac depression, while genetic deficiency of S100A9 or pharmacological blockade of S100A8/A9 with ABR-238901 prevented or reversed myocardial dysfunction and reduced systemic inflammation (Jakobsson et al., 2023)