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At the kidney level, uptake of glutathione-Hg conjugates occurs mainly at the luminal plasma membrane of proximal tubular epithelial cells 12,34

The authors of a 2018 Cochrane review concluded that, Acetylcysteine should be given to people at risk of toxicity including people presenting with liver failure. However, the optimal dose and duration in these situations is not clear, as randomized clinical trials are lacking

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