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Silibinin improves tumor immunity Silibinin inhibits tumor growth through immunomodulatory activities, such as regulating immune cells (Tregs, macrophages, DCs, NK cell), inhibiting inflammatory cytokines (IFN- , IL-2, IL-6, IL-10, IL-12, TNF- , and TGF- ), and modulating immune check points (PD-L1 and PD-1) [889,890,891,892,893]

doi: 10.1152/ajprenal.00240.2014 98 ChenGLiuYGoetzRFuLJayaramanSHuMCet al

Complementing these findings, (Pan et al

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Without adequate copper delivery to these enzymes, collagen forms but does not properly crosslink, producing weaker tissue