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However, concern has been raised regarding EPA and DHA supplementation when there is excess iron in the body [72] because lipid peroxides are derived from the oxidation of the PUFAs in cell membranes [6]

Woodmass JM, Mohan R , Stuart MJ, Krych AJ

Although the mechanism by which oxidizing agents is distinct from ionizing radiation, conditions like severe sepsis and septic shock also create an oxidation-rich environment that leads to the depletion of natural cellular antioxidants (such as glutathione) and contributes to cellular injury and death