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A second form of renal toxicity, generally associated to NSAIDs, is observed in patients with conditions causing decreased blood volume or renal flow where the prostaglandins have a primordial role in maintaining the renal perfusion

Excretion: In 64 patients with cancer and bone metastases on average ( SD) 39 16% of the administered zoledronic acid dose was recovered in the urine within 24 hours, with only trace amounts of drug found in urine post Day 2