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As a conclusion, inflammation, and stress regularly induce insulin resistance by common mechanisms

Other pathways impacted by APOE4 in our study, including methylmalonyl metabolism, fatty acid oxidation, and sirtuin signaling in females and branched-chain amino acid catabolism and mitochondrial translation in males, also play important roles in energy metabolism through their direct involvement in fuel oxidation, metabolic signaling, or synthesis of electron transport chain proteins

These immune disturbances together sustain a pro-inflammatory microenvironment that accelerates tumor formation

Following LCMS/MS analysis, the PRM acquisition approach was adopted to collect data from every sample to measure target protein levels

Microglia regulate central nervous system myelin growth and integrity