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a 2025 literature review identified limited clinical evidence, including a retrospective study of 12 patients with knee pain and a Phase I trial in healthy volunteers whose results were not submitted

Billington CK et al (2013): cAMP Regulation of Airway Smooth Muscle Function

Hofmann NA, Ortner A, Jacamo RO, Reinisch A, Schallmoser K, Fruewirth M, Diwoky C, Rohban R, Beham-Schmid C, Andreeff M , Strunk D

Neurodivergence and Anxiety Disorders: Often reported alongside physical symptoms, and can influence how patients are perceived and treated by the medical system

These have demonstrated that photoaging can result in either higher or lower leaching rates