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doi: 10.1093/ajcn/61.4.1058

This suggests that the cells rely on GPX4 to resist oxidative stress, and this could potentially increase their sensitivity to RSL3, a ferroptosis inducer that targets GPX4

Su, S., Chien, M., Lin, C., Chen, M

Abnormalities in various metabolic pathways such as glucose 80 or amino acid metabolic system 81 in chondrocytes have been implicated in activating catabolic cascades in osteoarthritic cartilage 82