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The identification of these metabolites as O -glucuronide conjugates is further supported by the presence of fragment ions at m/z 159.0285 (C 6 H 7 O 5 + , 1.9 ppm), 131.0342 (C 5 H 7 O 4 + , 2.4 ppm), and 85.0282 (C 4 H 5 O 2 + , 2.4 ppm)

The intestinal epithelial layer, therefore, plays an important role in limiting the translocation of bacterial molecular mimics of host components that could promote the development of ADs such as SLE (Fig

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In order to improve the therapeutic effect of natural medicines, the research and development of natural medicines derivatives are also one of the current hot spots