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10.1016/j.hipert.2020.09.001 169

Pathogenesis of amyotrophic lateral sclerosis

The human evidence is positive but more limited in scale than the prescription standards of care (minoxidil and 5-AR inhibitors), which have decades of large randomized controlled trials behind them

Daz LA, Fuentes-Lpez E, Ayares G, Idalsoaga F, Arnold J, Valverde MA, Perez D, et al

Metabolism is via the CYP450 and/or monoamine oxidase (MAO)-A system, supporting evaluation for significance in patients with hepatic disease or on concurrent drugs