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Investigations into the methanol extract of Muntingia calabura have highlighted the involvement of the L-arginine/NO/cGMP pathway in mediating its antinociceptive effects (Zakaria et al., 2006)

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2.2 Central nervous system Noradrenaline, present in the CNS, primarily originates from the locus coeruleus and is a substantial mediator participating in arousal, fear, anxiety, and other stress-mediated responses (75)

Without such trials, it is not possible to definitively establish what dose BPC-157 do in the human body, what an appropriate human research framework would look like, what the human safety profile is, or what conditions if any it might effectively address in clinical practice

doi: 10.1093/ajcn/55.1.131 17