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The underlying mechanism has been attributed to MC4R-related signaling, which may support neuronal resilience and enhance regenerative potential after injury

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Glycogenesis creation of storage carbohydrate polymer from glucose and controlled by the action of the enzyme complex, glycogen synthase , and regulated by c-AMP-dependent protein kinase , promoted by the action of insulin

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The decreased CAT activity shown by women affected by VP can therefore be attributed to three different mechanisms: (1) as CAT has haem as a prosthetic group, the limitation in haem synthesis attributed to the genetic defect in PPOX could lead to limitations in the synthesis of active CAT, thus reducing total enzyme activity