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in the event of a deficiency of B12, B9, or both, cells are unable to successfully duplicate DNA and there is a delay in cell division, which leads to an alteration of this process, stalling in the growth phase and being unable to move on to the mitosis phase

They are a rich source of soluble factors such as ROS, peptides, cytokines and enzymes that exert antimicrobial activities [257]

Vitamin B12 is a cobalamin, formed by four pyrrole rings (tetrapyrrole structure) that form a corrin nucleus around a central cobalt atom