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4.1.1 Increased glycolysis in hypoxia, pro-inflammatory conditions and monocyte/macrophage trained immunity In hypoxic conditions - such as in atherosclerotic lesions with a high content of proliferating and metabolically active cells -, glycolysis is upregulated through increased hypoxia-inducing factor (HIF)1 mediated expression of glycolysis-regulating genes, such as PFKFB3 (Folco et al., 2011

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(2010) 12:R225