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Key Takeaways 5-Amino-1MQ inhibits nicotinamide N-methyltransferase (NNMT), increasing cellular NAD+ levels by preserving nicotinamide for NAD+ salvage pathways rather than methylation to N-methyl nicotinamide

The effect held in beta-3 knockout mice for acute energy expenditure, suggesting AOD-9604 has more than one pathway it leans on

Tube formation assay The extracellular matrix gel-induced tube formation assay was used as an in vitro measurement of angiogenesis

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Add diluent slowly down the side of the vial do not inject directly onto the lyophilised cake and allow the powder to dissolve without vigorous shaking