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The mechanism may be related to the decreased inflow of iron, TF and TFR1, the upregulation of GPX4, xCT, and FTH1, and the downregulation of ACSL4, MDA and LPO levels

In addition, the activities of key enzymes that are involved in MG metabolism, including GlO1, GlO2, and D-lactate dehydrogenase, were significantly reduced in the kidney injury model, indicating a decreased MG detoxification capacity

Neel noted that, with this new immunotherapy approach, theres also the potential that the targeted drugs dont need to be able to kill cancer cells, only to be able to bind to their target