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For instance, treatments with apple polysaccharides, flos lanicera, and Bofutsushosanan herbal remedy from Japanhave been successful in promoting the growth of beneficial bacteria like Lactobacillus and Bacteroidetes , improving intestinal barrier integrity, and decreasing pro-inflammatory cytokines such as TNF- and IL-6 [117,118,119]

However, in healthy people with normal dietary habits, it is well-recognized that hyponatremia is very difficult to achieve ( EFSA 2010

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