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Older adults are at risk of magnesium deficiency due to reduced intestinal absorption and increased urinary excretion

Oral absorption is considered too undependable to rely on in patients with pernicious anemia or other conditions resulting in malabsorption of vitamin B12

Several steps are involved, including the reduction of iron to a ferrous state, apical uptake, intracellular storage or transcellular trafficking, and basolateral release [8,9]

It also allows for fairly reliable conclusions to be drawn about the B12 supply

Saborio GP, Permanne B, Soto C (2001) Sensitive detection of pathological prion protein by cyclic amplification of protein misfolding