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and the current waves of Fil-Am, Fil-European, Kopinoy, and Japinoy (Fig

Excessive ROS could damage the cellular components, leading to neuronal death

Currently, in vivo brain markers in AD and MCI mainly include positron emission tomography scanning of amyloid, tau, and glucose metabolism, as well as brain structural imaging using MRI such as hippocampal atrophy [81]

N Engl J Med 382(20):19261932

Nonsteroidal AIs are chemicals which are not subjected to much metabolic changes within cells, whereas the structure of the steroidal aromatase inhibitors can undergo slight changes within cells giving rise to different active sterols (intracrinology) 7