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Because evidence suggests that HIV infection causes oxidative stress and damages epithelial barrier function in the lung, Fan et al studied alveolar epithelial cells from HIV-1 transgenic rats cells in vitro and found that Nrf2 activation both improved the expression of tight junction proteins and also restored the ability of the cells to form tight barriers

"Identification of a virulence gene cluster of Mycobacterium tuberculosis by signature-tagged transposon mutagenesis"

Further, mitochondrial structural damage compromises membrane integrity, which allows the release of mitochondrial contents such as mtDNA, cardiolipin, and mitochondrial proteins into the cytosol

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Alpha lipoic acid is a naturally occurring compound produced in the mitochondria of our cells