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However, these methods do not consider aspects of molecular structures such as 3D folding

The main differences between these are 1) how strongly they activate opioid receptors and 2) the length of time that they are active in the body

10.3390/biom15010016 6 CaiL.LiuX.GuoQ.HuangQ.ZhangQ.CaoZ

Waterman E, Lockwood B