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195,196 The different types of cell senescence-associated DNA methylation also lead to distinct gene expression patterns and cell phenotypes

This process is facilitated by an acidic environment, resulting in spontaneous production of H 2 O 2 at the tumor site

Representative blots of at least two independent experiments are shown

Recent studies using tissue/cell-specific gene knockout mouse models and cell culture techniques have clearly demonstrated that locally produced IGF-I is more critical than the systemic IGF-I in supporting embryonic and postnatal skeletal development and bone remodeling