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Sustained intra-cartilage delivery of interleukin-1 receptor antagonist using cationic peptide and protein-based carriers

The mechanism: KPV translocates into the cell nucleus and blocks the interaction between importin-alpha3 and the p65/RelA subunit of NF-kB, preventing p65 from reaching its transcriptional targets

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While male mice exhibited minimal changes in tumor formation, treatment of female mice sharply delayed tumor growth (Fig

At the same time, the digital mixing system can control temperatures leading to faucets, showers, etc