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Strong sun exposure is the most common trigger, especially in Bangladesh, where UV rays easily cause tanning, dark spots, and pigmentation like melasma

Activation of the Nrf2ARE (antioxidant response element) signaling pathway is central to this process, triggering transcription of cytoprotective genes that reduce inflammation and support tissue repair (74)

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In a 2014 article published in Molecular Therapy , author Michelangelo Campanella noted that a particular peptide showed the ability to increase testosterone production