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It has also been suggested that for effectively inducing demyelinating disease pathology via cuprizone, mice need to additionally intake the cuprizone powder through the skin and respiratory system 28

This mechanism closely aligns with conventional antidepressant pharmacology, although Rhodiola exerts its effects within a broader adaptogenic framework rather than via selective receptor or transporter blockade

It also helps protect against oxidative stress by conjugating to GSH, neutralizing free radicals

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