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Curcumin has also displayed relevant suppressive effects on NF-kB signaling in immune cells, leading to a reduction in iNOS expression by macrophages and DCs (270), as well as neutrophils (271)

(PubMed) Valls N, Gormaz JG, Aguayo R, et al

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This could suggest that oxidation of a cysteine residue strategically positioned in the enzyme catalytic center constitutes a mechanism to selectively regulate only a subset of PTKs