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Novel formulations such as lipid nanoparticles, esterified derivatives, or intranasal carriers should be systematically compared for pharmacokinetics, bloodbrain barrier penetration, and clinical efficacy

Mechanistically, GDIL binds and re-localizes the nuclear protein XRN2 to the cytoplasm, where GDIL further serve as a scaffold for XRN2 to identify and degrade CHAC1 mRNA

Selenium Selenium (Se) is a trace mineral found naturally in various foods and nutritional supplements

Stroke by Inducing HDAC9-dependent Deacetylation of HIF-1 and Sp1, Promotes TfR1 Transcription and GPX4 Reduction, Thus Determining Ferroptotic Neuronal Death