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Under normal physiological conditions, NRF2 binds to Kelsey-like ECH-associated protein 1 (Keap1) in the cytoplasm and is degraded via the ubiquitin-proteasome pathway (Itoh et al., 1999)

Glutathione (GSH) works primarily by directly scavenging reactive oxygen species (ROS) and acting as a critical cofactor for glutathione peroxidase, the enzyme responsible for neutralizing hydrogen peroxide and lipid peroxides within your cells

Cytokine profiling was not performed, which would have provided additional insight into inflammatory drivers of micronutrient redistribution and oxidative stress

This finding, therefore, suggests that AP-1 drives the regulation of apoptosis in motor neurons (Iaccarino et al., 2011)